Simple and effective synthesis of functionalized (hydroxymethylene)bis(phosphonic) acids

Zhirkova A.M., Zaitsev K.V., Prishchenko A.A., Vasiliev M.V., Kotova M.V., Uschakova K.A., Martirosyan L.A., Perminova I.V.

Mendeleev Communications, 2023, , doi: 10.1016/j.mencom.2024.04.029

Abstract

‘Technical’ tris(trimethylsilyl) phosphite, (Me3SiO)3P, as a mixture with (Me3SiO)2P(O)H and (Me3SiO)3P(O) (71 :\ 20 :\ 9) was obtained upon the action of (Me Si) NH on phosphorous acid H3PO3 in the presence of catalytic amount of Me3SiCl. The action of this material on acid chlorides RC(O)Cl affords (hydroxymethylene)bis(phosphonic) acids RC(OH)[P(O)(OH)2]2 in preparative yields.